GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs60843830 | 1 | rs62114497 | chr2:214837 | SH3YL1 | chr2:218138-264810:- | -0.47 | -6.22 | 4.55E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs62114501 | chr2:231741 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.46 | 1.34E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs62114505 | chr2:242426 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.59 | 6.96E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs62114544 | chr2:269679 | SH3YL1 | chr2:218138-264810:- | -0.5 | -6.7 | 3.72E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9309473 | 1 | rs62151652 | chr2:73700131 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.63 | 8.31E-8 | Metabolite levels |
| UCEC | cis | rs10935120 | 1 | rs62269547 | chr3:134214042 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.64 | 7.4E-6 | Height |
| UCEC | cis | rs568617 | 1 | rs641018 | chr11:65655393 | CTSW | chr11:65647284-65651212:+ | -0.5 | -8.35 | 3.96E-14 | Crohn's disease |
| UCEC | cis | rs4660306 | 1 | rs6429567 | chr1:45956700 | CCDC163P | chr1:45960581-45965646:- | -0.57 | -7.3 | 1.52E-11 | Homocysteine levels |
| UCEC | cis | rs4660306 | 1 | rs6429569 | chr1:46001330 | CCDC163P | chr1:45960581-45965646:- | -0.45 | -6.02 | 1.23E-8 | Homocysteine levels |
| UCEC | cis | rs10935120 | 1 | rs6439484 | chr3:134249899 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.61 | 8.54E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs6439487 | chr3:134260860 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs10461617 | 1 | rs6450408 | chr5:56098146 | C5orf35 | chr5:56205103-56213010:+ | 0.55 | 6.09 | 8.78E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs6450409 | chr5:56101399 | C5orf35 | chr5:56205103-56213010:+ | 0.47 | 5.58 | 1.06E-7 | Type 2 diabetes |
| UCEC | cis | rs1577917 | 1 | rs6454513 | chr6:86720049 | SNHG5 | chr6:86386726-86388451:- | 0.45 | 5.95 | 1.81E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9473555 | 1 | rs6458690 | chr6:49411619 | MUT | chr6:49398994-49431031:- | 0.35 | 5.93 | 2.01E-8 | Folate pathway vitamin levels |